Born and raised in San Jose, California, Anjelah Johnson is of Mexican and Native American descent. Johnson was a professional cheerleader for the Oakland Raiders, where she was named Rookie of the Year. Later, she appeared on MADtv as a series regular, which spawned internet sensations "Nail Salon" and "Bon Qui Qui." Johnson was nominated for an ALMA Award for her work on the show. Johnson can also be seen as a live action character in the film Alvin and the Chipmunks: The Squeakquel
alongside Jason Lee and the voices of Justin Long, Anna Faris, and Amy Poehler. Alvin and the Chipmunks: The Squeakquel is now available on Blu-ray and DVD.
Johnson starred in Our Family Wedding. She plays the feisty sister of America Ferrera in this comedy about two families coming together for a wedding. The film also stars Oscar Award winner Forest Whitaker, Taye Diggs, Carlos Mencia, and Regina King. Johnson recently completed working on the animated film Marmaduke where she lends her voice along with Emma Stone, Owen Wilson, and Jeremy Piven. Marmaduke hit theaters on June 4, 2010. Johnson currently resides in Los Angeles and continues to tour with her stand up show in various cities around in the United States.