Deon Cole is originally from the South Side of Chicago. He is one of the most requested headlining comedians in the club and college circuits nationwide. He is also a successful actor, having appeared in MTV's Nick Cannon Presents: Short Circuitz and Nick Cannon Presents: Wild 'N Out, as well as Barbershop and Barbershop 2: Back in Business. As a stand up, he has been featured on The Tonight Show with Conan O'Brien, Comedy Central's Jamie Foxx Presents Laffapalooza, HBO's Def Comedy Jam, BET's Comicview, NBC's Showtime at the Apollo, BBC's The World Stands Up, and Starz's 1st Amendment Stand Up. Cole also had his own half-hour special on Comedy Central, which premiered in 2007.

After Cole's stand up appearance on The Tonight Show with Conan O'Brien, he was offered a job as a staff writer for the show and has since made multiple appearances as a commentator and sketch performer on the show. TV Guide declared “A star is born” after Cole's commentary pieces kept growing as a bit on the show. He is currently a featured act on Conan O'Brien's The Legally Prohibited from Being Funny on Television Tour.

Cole has been a featured comic in HBO's The Comedy Festival in Aspen and the CanWest Comedy Fest in Vancouver. He was a finalist in NBC's Stand Up for Diversity showcase, and he won BET's Robin Harris Award for Most Original Comic. He has been part of several tours, including the Cole-Cola World European Tour for the Troops, which traveled to Germany, Amsterdam, Belgium, Japan, and Korea, the BET Comedy Tour, the Def Comedy Jam tour, Budweiser Superfest with R. Kelly, and he has also has toured with Mary J. Blige. Cole's charismatic personality and original style make him one of the most popular performers in the comedy scene today.