Maniscalco's comedy is impeccably paced and chock-full of seething observations on daily human behavior. Most recently, he has starred in the film Vince Vaughn's Wild West Comedy Show, and his Comedy Central Presents special is the highest rated comedy special on On Demand.
Maniscalco's humor also created memorable spots on The Tonight Show with Jay Leno, Comedy Central’s Premium Blend, twice on the The Late Late Show with Craig Ferguson, Comics Unleashed with Byron Allen, and Showtime's Comics without Borders. His comedy is so diverse, it has enabled him to work with such prestigious acts as BB King, Al Green, Anita Baker, Gladys Knight, and Dennis Miller.
In addition to his television and film appearances, Maniscalco's brand of comedy has worldwide appeal as he embarks on a Middle Eastern tour with the creators of the Axis of Evil Comedy Tour this winter. He has also inked a distribution deal with Salient Media for his hour-long DVD which will air on Comedy Central in February 2009. Although a native born Chicagoan, Maniscalco currently resides in Los Angeles.