Peter-john Byrnes has been described as having "the voice of an NPR announcer and the mind of an apocalyptic street preacher." He eschews typical subject matter in favor of informing audiences about the inevitability of human decline, the end of civilization, and other light-hearted fare. He also uses words like "eschews." He averages two H.P. Lovecraft references per show.

He has opened for Erin Foley, Orlando Jones, Cameron Esposito, Stewart Huff, Dan Telfer, and Hari Kondabolu. Festival appearances include Limestone Comedy Festival 2013 (Bloomington IN), Just For Laughs Chicago 2013, and the Arch City Comedy Festival 2015 (Columbus OH).

His album recording, "American History XXX," played to sold-out audiences at the Indianapolis Fringe festival and was listed as a top pick by both the alternative weekly NUVO and the Indianapolis Star newspaper. It will be released by OnTour Records in 2019.

He is also a contributor to MAD Magazine, a gig that makes his inner nine year-old very happy indeed.