Wolfson moved to Los Angeles in 2016 to pursue a career in comedy. She had performed stand-up comedy in locations, such as the L.A. Comedy Club and the Laugh Factory at the Tropicana.

Wolfson runs a YouTube channel, The Budd, which is about smoking marijuana. In college, she began smoking cannabis recreationally, later establishing her YouTube channel and own podcast about marijuana. She also starred on Snoop Dogg's media platform Merry Jane in 2017, being described as the "Ultimate Millennial Stoner Girl".

Wolfson starred in Jackass Forever (2022), the second woman to star in the franchise (after Stephanie Hodge), and first woman to star in the movie franchise. According to director and producer Jeff Tremaine, she was recruited to the franchise after Johnny Knoxville saw her Instagram in 2019 and thought she was funny. A self-described "MTV kid", she participated in multiple stunts in the film, including licking a taser and being stung on the lips by a scorpion. After filming, she praised the on-set culture.